北京大学肿瘤医院

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病理科 - 薛卫成

薛卫成简介

学历及工作简历:现任北京大学临床肿瘤学院/北京肿瘤医院病理科主任医师,博士学位。硕士研究生导师。1993年毕业于北京大学医学部(原北京医科大学)基础医学系,分配到人民医院病理科工作,1998年晋升主治医师。1999年9月至2000年3月获“郑裕彤博士奖助金”赴香港大学病理学系访问学习;2000年9月至2004年8月就读于香港大学病理学系,从事肿瘤病理研究,并取得博士学位。2004年9月返回北京大学人民医院病理科工作;2005年8月晋升副主任医师;2006年8月晋升副教授。2007年4月引进到北京大学临床肿瘤学院/北京肿瘤医院病理科。2012年晋升主任医师

学术团体任职:卫生部结直肠癌诊疗规范病理专家;中华医学会妇科肿瘤分会病理学组委员;中国老年学学会老年肿瘤专业委员会委员;《中华病理学杂志》编委;《诊断病理学杂志》编委;《Chinese Journal of Cancer Research》编委;《临床与实验病理学》编委;《中华医学杂志》、《癌症》、《中国肿瘤临床》审稿专家。

论著发表及科研成果:至今发表SCI论文45篇(第一作者10篇)。国内核心杂志论文49篇(第一作者及责任作者19篇)。主译《乳腺病理学:粗针活检诊断》(2008年7月出版,人民卫生出版社,60万字)。主译《软组织肿瘤》(2010年10月出版,北京大学医学出版社,225万字)。参译《阿克曼外科病理学》、《诊断外科病理学》、《女性生殖道病理学》《妇产科诊断病理学》《肿瘤组织病理学诊断》。参与新版WHO分类及诊断标准系列《皮肤肿瘤病理学和遗传学》分册和《乳腺及女性生殖器官肿瘤病理学和遗传学》分册的翻译和审校工作。参编《乳腺病理学》、《乳腺干细胞调控与癌变》。曾主持一项(30672224,题目:卵巢癌表达差异性基因的组织芯片验证及甲基化研究)并参与两项国家自然科学基金面上项目研究。北京市“十百千”卫生人才经费资助“百”层次人选。北京市卫生系统高层次卫生人才培养计划“学科骨干”层次人选。

List of Publications:

In English:

1.Xue WC, Cheung AN. Endometrial stromal sarcoma of uterus. Best Pract Res Pract Res Clin Obstet Gynaecol 2011;25: 719-732.

2.Xue WC, Feng HC, Chan KYK, Chiu PM, Ngan HYS, Khoo US, Tsao SW, Chan KW, Cheung ANY. Id helix-loop-helix proteins are differentially expressed in gestational trophoblastic disease. Histopathology 2005; 47: 303-309

3.Xue WC, Chan KYK, Feng HC, Chiu PM, Ngan HYS, Tsao SW, Cheung ANY. Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma. J Mol Diagn 2004; 6:326-334

4.Xue WC, Khoo US, Ngan HYS, Chan KYK, Ip PPC, Tsao SW, Cheung ANY. C-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions. Int J Gynecol Pathol 2004; 23: 145-150

5.Xue WC, Feng HC, Tsao SW, Chan KYK, Ngan HYS, Chiu PM, MacCalman CD, Cheung ANY. Methylation status and expression of E-cadherin and cadherin-11 in gestational trophoblastic diseases. Int J Gynecol Cancer 2003; 13: 879-888

6.Xue WC, Khoo US, Ngan HYS, Chan KYK, Chiu PM, Tsao SW, Cheung ANY. Minichromosome Maintenance Protein 7 Expression in Gestational Trophoblastic Disease: Correlation with Ki67, PCNA and Clinicopathologic Parameters. Histopathology 2003; 43: 485-490

7.Xue WC, Guan XY, Ngan HYS, Shen DH, Khoo US, Cheung ANY. Malignant placental site trophoblastic tumor: A cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization. Cancer 2001; 94: 2288-2294

8.Xue WC, Hui YZ. Melanotic oncocytic metaplasia of the nasopharynx. Histopathology 1999;35:481-482.

9.Li SS*, Xue WC*, Khoo US, Ngan HYS, Chan KYK, Tam IYS, Chiu PM, Ip PPC, Tam KF, Cheung ANY. Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: a tissue microarray and clinicopathologic analysis. Histopathology 2005; 46: 307-313

10.Du CZ, Xue WC*, Li JY,Cai Y, Gu J. Morphology and prognostic value of tumor budding in rectal cancer after neoadjuvant radiotherapy. Hum Pathol 2012;43:1061-1067

11.Liao XY, Xue WC, Shen DH, Ngan HY, Siu MK, Cheung AN. p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas. Histopathology 2007;51(4):477-483.

12.Zhang HJ, Xue WC, Siu MK, Liao XY, Ngan HY, Cheung AN. P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics. Int J Gynecol Pathol. 2009 Mar;28(2):172-8

13.Du CZ, Xue WC, Cai Y, Li M, Gu J. Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: a retrospective cohort study. World J Gastroenterol. 2009 Aug 14;15(30):3793-8.

14.Wang Y, Xue WC, Liu VW, Ngan HY. Detection of mosaic pattern of mitochondrial DNA alterations in different populations of cells from the same endometrial tumor. Mitochondrion. 2007; 7:171-175

15.Fong PY, Xue WC, Ngan HY, Chiu PM, Chan KY, Tsao SW, Cheung AN. Caspase activity is downregulated in choriocarcinoma: a cDNA array differential expression study. J Clin Pathol 2006; 59: 179-183

16.Fong PY, Xue WC, Ngan HYS, Chan KYK, Khoo US, Tsao SW, Chiu PM, Man LS, Cheung ANY. Mcl-1 expressionin gestational trophoblastic disease correlates with clinical outcome: a differential expression study. Cancer 2005; 103: 268-276

17.Leung TW, Xue WC, Cheung ANY, Khoo US, Ngan HYS. Proliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervix. Gynecol Oncol 2004; 92: 866-872

18.Hui YZ, Xue WC, Dai L, Yu H, Guo QX, Qian HN. Uterine involvement by intra-abdominal desmoplastic small round cell tumor in a 63-year-old-female. Int J Gynecol Cancer 1998; 8: 434-438

19.Cheung AN, Zhang HJ, Xue WC, Siu MK. Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives. Future Oncol. 2009 Mar;5(2):217-31

20.Wang Y, Liu VW, Xue WC, Cheung AN, Ngan HY. Association of decreased mitochondrial DNA content with ovarian cancer progression. Br J Cancer. 2006;95:1087-1091

21.Wang Y, Liu VW, Xue WC, Tsang PC, Cheung AN, Ngan HY. The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: a quantitative study using laser-captured microdissected tissues. Gynecol Oncol 2005; 98: 104-110

22.Feng HC, Cheung ANY, Xue WC, Wang Y, Wang X, Fu S, Wang Q, Ngan HY, Tsao SW. Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma. Gynecol Oncol 2004;94:375-382

23.Shen DH, Khoo US, Xue WC, Ngan HYS, Wang JL, Liu VW, Chan YK, Cheung ANY. Primary peritoneal malignant mixed mullerian tumors: A clinicopathological, immunohistochemical and genetic study. Cancer 2001; 91: 1052-1060

24.Wang X, Khoo US, Xue WC, Cheung ANY. Cervical and peritoneal fluid cytology in uterine sarcomas. Acta Cytol 2002; 46: 465-469

25.Shen DH, Khoo US, Xue WC, Cheung ANY. Ovarian mature cystic teratoma with malignant transformation. An interphase cytogenetic study. Int J Gynecol Pathol 1998; 17: 351-357

26.Feng HC, Tsao SW, Ngan HY, Xue WC, Kwan HS, Siu MKY, Liao XY, Wong E, Cheung ANY. Overexpression of prostate stem cell antigen is associated with gestational trophoblastic neoplasia. Histopathology 2008; 52: 167-174

27.Du CZ, Chen YC, Cai Y, Xue WC, Gu J. Oncologic outcomes of primary and post-irradiated early stage rectal cancer: a retrospective cohort study.World J Gastroenterol.2011;17(27):3229-34.

28.Zhang XY, Sun YS, Tang L, Xue WC, Zhang XP. Correlation of diffusion-weighted imaging data with apoptotic and proliferation indexes in CT26 colorectal tumor homografts in balb/c mouse. J Magn Reson Imaging 2011;33(5):1171-6.

29.Feng HC, Tsao SW, Ngan HY, Xue WC, Chiu PM, Cheung ANY. Differential expression of insulin-like growth factor binding protein 1 and ferritin light polypeptide in gestational trophoblastic neoplasia: combined cDNA suppression subtractive hybridization and microarray study. Cancer 2005; 104: 2409-2416

30.Khoo US, Chan KYK, Cheung ANY, Xue WC, Shen DH, Ngan HYS, Pang CP, Choy RKW, Poon AYA, Fung KY, Ozcelik H. Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a Founder mutation of BRCA1 identified in the Chinese population. Hum Mutat 2002; 19: 307-308

31.Liu SS, Tsang BK, Cheung ANY, Xue WC, Cheng DK, Ng TY, Wong LC, Ngan HYS. Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma. Eur J Cancer 2001; 37: 1104-1110

32.Shen DH, Ng TY, Khoo US, Xue WC, Cheung ANY. Pseudomyxoma peritonei--a heterogenous disease. Int J Gynaecol Obstet 1998; 62: 173-182

33.Wang Q, Tsao SW, Fu SB, Xue WC, Meng XN, Feng HC, Wong YC, Wang XH. Overexpression of Id-1 in gastric adenocarcinoma: implication for a novel diagnostic marker. Anticancer Res 2004; 24:881-886

34.Ho JW, Poon RT, Sun CK, Xue WC, Fan ST. Clinicopathologocal and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver. World J Gastroenterol 2005; 11:176-181

35.Du CZ, Li J, Cai Y, Sun YS, Xue WC, Gu J. Effect of multidisciplinary team treatment on outcomes of patients with gastrointestinal malignancy. World J Gastroenterol 2011;17(15):2013-8.

36.Chan QK, Ngan HY, Ip PP, Liu VW, Xue WC, Cheung AN. Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis - a differential expression and functional analysis. Carcinogenesis 2009 Jan 30(1):114-121.

37.Shen DH, Chan KY, Khoo US, Ngan HY, Xue WC, Chiu PM, Ip P, Cheung AN. Epigenetic and genetic alterations of p33ING1b in ovarian cancer. Carcinogenesis 2005;26:855-863

38.Chan QK, Khoo US, Ngan HY, Yang CQ, Xue WC, Chan KY, Chiu PM, Ip PP, Cheung AN. Single nucleotide polymorphism of pi-class glutathione s-transferase and susceptibility to endometrial carcinoma. Clin Cancer Res. 2005;11:2981-2985.

39.Lai CY, Chan KY, Khoo US, Ngan HY, Xue WC, Chiu PM, Tsao SW, Cheung ANY. Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization. Mod Pathol 2004; 17: 40-48

40.Cheung AN, Khoo US, Lai CY, Chan KY, Xue WC, Cheng DK, Chiu PM, Tsao SW, Ngan HY. Metastatic trophoblastic disease after an initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis. Cancer. 2004; 100: 1411-1417

41.Shen DH, Khoo US, Ngan HY, Ng TY, Chau MT, Xue WC, Cheung ANY. Coexisting epithelioid trophoblastic tumor and choriocarcinoma of the uterus following a chemoresistant hydatidiform mole. Arch Pathol Lab Med 2003; 127: e291-e293

42.Feng HC, Tsao SW, Ngan HY, Kwan HS, Shih SM, Xue WC, Chiu PM, Chan KW, Cheung ANY. Differential gene expression identified in complete hydatidiform mole by combining suppression subtractive hybridization and cDNA microarray. Placenta. 2006; 47:521-526

43.Chiu PM, Feng HC, Benbrook DM, Ngan HY, Khoo US, Xue WC, Tsao SW, Chan KW, Cheung ANY. Effect of all-trans retinoic acid on tissue dynamic of choriocarcinoma cell lines: an organotypic model. J Clin Pathol 2006;59:845-850

44.Yang CQ, Chan KY, Ngan HY, Khoo US, Chiu PM, Chan QK, Xue WC, Cheung ANY. Single nucleotide polymorphisms of follicle stimulating hormone receptor are associated with ovarian cancer susceptibility. Carcinogenesis. 2006 ;27:1502-1506

45.Chan QKY, Khoo US, Chan KYK, Ngan HYS, Li SS, Chiu PM, Man LS, Ip PPC, Xue WC, Cheung ANY. Promoter Methylation and Differential Expression of pi-class Glutathione-S-Transferase in Endometrial Carcinoma. J Mol Diagn 2004; 7: 8-16

In Chinese:

1.薛卫成,回允中,廖松林:鼻咽粘膜黑色素性嗜酸细胞化生一例。中华病理学杂志1998;27:452

2.薛卫成,朱积川,回允中:阴茎中隔囊肿二例报告。中华泌尿外科杂志1998;252

3.薛卫成,董建强,回允中:婴儿纤维性错构瘤3例。临床与实验病理学杂志1998;14:364

4.薛卫成,董建强,回允中,廖松林:肝外胆管原发透明细胞癌一例。中华病理学杂志1999;28:284

5.薛卫成,董建强,回允中:子宫平滑肌瘤伴有大量淋巴组织浸润一例。中华病理学杂志1999;28:476

6.薛卫成,阚秀:甲状腺外甲状腺组织的意义。诊断病理学杂志1999;6:114

7.薛卫成,冷希圣,阚秀,回允中:纤维板层型肝细胞癌的临床及病理学特征。中华普通外科杂志2000;15:57

8.薛卫成,张小东,王晓峰,许克新,朱积川,回允中:多房性囊性肾细胞癌一例报告。中华泌尿外科杂志2000;21:248

9.薛卫成,任建林,冷希圣:成人甲状腺成熟性畸胎瘤一例。中华普通外科杂志2000;15:351

10.薛卫成,沈丹华,阚秀:乳腺粗针穿刺活检病理检查。诊断病理学杂志 2006;13(3):227-229.

11.薛卫成,钱利华,沈丹华,鲍冬梅,廖松林:膀胱肾源性腺瘤临床病理观察。诊断病理学杂志 2006;13(5):351-353.

12.薛卫成,回允中:甲状腺乳头状癌和滤泡癌病理诊断中的一些问题。中华病理学杂志2007;36(4):220-223

13.薛卫成,阚秀:介绍乳腺癌TNM分期系统(第6版)。诊断病理学杂志 2008;15(3):161-164

14.薛卫成,沈丹华,张雅贤,冯会臣: 妊娠滋养细胞恶性转化的研究进展中国妇产科临床杂志2007; 8(5):397-398

15.薛卫成:介绍乳腺癌TNM分期系统(第7版)。诊断病理学杂志 2010;17(4):241-244

16.薛卫成,顾晋:第7版结直肠癌TNM分期(2010)的变化及意义。中华外科杂志 2010 ;48(21):1605-1606.

17.杜长征,张吉水,李明,赵军,彭亦凡,姚云峰,薛卫成*,顾晋:青年与中老年进展期直肠癌患者新辅助放疗后的临床病理学比较研究。中华外科杂志2010;48(21):1616-1620

18.冯勤,李向红,陈钊,何京生,王春旭,周立新,薛卫成*:非小细胞肺癌表皮生长因子受体基因突变检测及其与临床病理特征的相关性。中华病理学杂志 2011;40(10):660-663

19.苏韬,薛卫成*:胃肠道间质瘤的TNM分期系统简介。中华病理学杂志 2011;40(2):141-142

20.阚秀,薛卫成:乳腺癌中PS2基因与雌激素及孕激素受体。中华肿瘤杂志1998;20:237-238

21.阚秀,薛卫成, 张晓波:“交界性肿瘤及交界性病变”综览。肿瘤研究与临床2007;19:850-853

22.丁华野,薛卫成:应关注乳腺癌病理诊断中的新问题。中华病理学杂志2008;37(2):75-78

23.彭亦凡,薛卫成,顾晋:直肠神经内分泌癌16例临床分析。中华胃肠外科杂志 2009;12(2):170-173

24.顾国利,杜长征,薛卫成,顾晋,赵军:结直肠癌p27表达与Ki67、p170、MLH1、MSH2、MSH6的关系及意义。世界华人消化杂志 2012;20(23):2157-2161

25.武爱文,陕飞,薛卫成,董彬,季加孚:胃癌新辅助化疗后原发灶病理完全缓解患者的病理学观察。中华胃肠外科杂志 2011;14(8):596-598

26.杜长征,王晓春,薛卫成,顾晋:新辅助治疗在直肠癌脉管癌栓中的临床意义。中华消化外科杂志 2010;9(4):265-268

27.邵汇琳,沈丹华,薛卫成,李艺,虞有智卵巢上皮性肿瘤的临床病理特征及其细胞周期素D1和p53蛋白表达的研究。中华妇产科杂志 2007;42(4): 227-232

28.鲍冬梅,沈丹华,薛卫成:宫颈微小浸润性鳞状细胞癌。中华病理学杂志 2006;35(8):491-493

29.李静,张乐萍,薛卫成:周期蛋白D在小儿急性淋巴细胞白血病骨髓单个核细胞中的表达及意义。中华儿科杂志2000;38:113

30.张雅贤,邱玮璇,薛卫成,沈丹华:妊娠滋养细胞病变的研究进展。中华病理学杂志2003;32:373-375

31.虞有智,林敏,薛卫成,宋秋静,沈丹华:免疫组织化学三重染色技术。中华病理学杂志2005;34:244-245

32.许克新,王向红,薛卫成,王晓峰,侯树坤:MAD2和p55CDC在前列腺癌组织中的表达及其与前列腺癌分级的相关性。北京大学学报(医学版)2003;35:586-590

33.沈丹华,张雅贤,薛卫成,颜婉嫦:卵巢成熟性囊性畸胎瘤恶变临床病理分析及人类乳头瘤病毒检测。北京医科大学学报1999;31:331-334

34.刘毅强,孙宇,李忠武,薛卫成,陆爱平,李吉友:穿刺活检在诊断肝血管平滑肌脂肪瘤中的价值。诊断病理学杂志 2011;18:52-55

35.熊六林,石军,郑珠颖,薛卫成,黄晓波:高强度聚焦超声焦域理想温度段及作用时间的实验探讨。中华医学超声杂志(电子版) , 2009;6(1): 5-7

36.富琪,魏丽惠,回允中,薛卫成,虞幸:卵巢成熟性畸胎瘤恶变。北京医科大学学报1998;30:261-263

37.富琪,魏丽惠,钱和年,薛卫成:卵巢冠乳头状囊腺癌一例。中华妇产科杂志1995;30:657

38.沈丹华,阚秀,虞有智,薛卫成:5例肛管直肠恶性黑色素瘤的临床病理分析。诊断病理学杂志1994;1:88-89

39.蒲永林,赵延乐,薛卫成,朱建钢,尹璧清,阚秀,王亚敏,石庭森:顺铂壳聚糖微球肝动脉栓塞化疗的动物实验和治疗肝癌的临床研究。北京医科大学学报1995;27:381-383

40.宫恩聪,刘叔平,鄂文,钟镐镐,衡万杰,薛卫成,吴秉铨,侯宽永,张同林,钟国萍,李崇延:套式聚合酶链式反应检测血库血液样品中丙型肝炎病毒的研究。北京医科大学学报1995;27:增刊170

41.宁向群,宫恩聪,吴秉铨,刘叔平,薛卫成,刘翠苓,王玉萍,张同林,吕愈敏:腺瘤癌变与p53过度表达。北京医科大学学报1995;27:增刊174

42.运用PCR-SSCP及免疫组化方法检测大肠肿瘤及粪便脱落细胞中p53基因突变。中华消化杂志1996;16:115

43.高子芬,王洪海,潘增刚,赵向荣,张晓明,薛卫成,刘淑云,李宁,马兰花,侯亮,杨京平,韩志惠,廖松林:上呼吸道淋巴瘤的病理、免疫表型及其与EB病毒相关性的研究。中华病理学杂志1998;27:251-254

44.顾晋,马朝来,叶颖江,薛卫成,曲军,赵永东,于永祥,冷希圣,祝学光:结肠直肠癌术前区域动脉灌注化疗的临床病理观察。中华外科杂志1999;37:333

45.安丽萍,王悦,叶雪,昌晓红,薛卫成,成夜霞,程洪艳,张丽,崔恒:粘着斑激酶在卵巢上皮性癌中的表达及意义。中国妇产科临床杂志2007; 8(5):365-368

46.张景珍,田新良,代亚辉,樊薇,梁皓,薛卫成:长骨双原发非霍奇金恶性淋巴瘤一例报告。中国煤炭工业医学杂志

47.刘艳丽,王颖,聂增尧,鲍冬梅,朱桂兰,薛卫成,回允中:非功能性甲状旁腺囊肿五例的临床分析。中华普通外科杂志2002;17:356-357

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