医学博士，主任医师，教授，博士生导师。国家级人才项目入选者，政府特贴专家。 

擅长：长期从事肺癌、食管癌的外科治疗、围术期综合治疗及转化医学研究。主要研究领域：复杂疑难肺癌和食管癌手术治疗和快速康复；复杂疑难胸部肿瘤的新型药物临床研究，胸部肿瘤早诊、鉴诊标志物研发应用，新型数字技术与肺癌诊疗全流程管理。 

兼任：国际肺癌研究协会（IASLC）分期与预后委员会委员。中华医学会肿瘤分会委员；中国医师协会肿瘤胸外科分会常委、多学科诊疗专委会常委；中国医促会胸外科分会常委；中国临床肿瘤学会（CSCO）智慧医疗专家委员会副主委，非小细胞肺癌专家委员会委员；北京医学会肿瘤学分会副主委，胸外科分会常委。

主持多项国家及省部级科研项目，目前在国际同行评议杂志发表论文90余篇，代表性论文发表在Cell Discovery, Molecular Cancer，STTT, Cell Stem Cell, PNAS, EBioMedicine, Int J Surg，Cancer Research，Molecular Therapy等国际主要期刊。主编出版《老年肺癌综合治疗学》、《肺癌规范化手术》、《肺癌标准化手术图谱》、《微创肺切除术国际进展与中国实践荟萃》等多部专著。副主编（或参编）《临床医学概论》、《外科学》、《CSCO原发性肺癌诊疗指南》等多部教材和指南编委。

荣耀医者金柳叶刀奖（2025），中国抗癌协会科技奖二等奖（2024），北京市教育系统“教书育人先锋人选”（2023），西藏自治区优秀教育援藏人才（2022），北京医管中心登峰人才（2020），北京市百千万人才工程（2018），华夏医学科技奖二等奖（第二完成人）（2016），“北京市优秀中青年医师”称号获得者（2012）。

主要研究领域：复杂疑难肺癌和食管癌手术治疗和快速康复；复杂疑难胸部肿瘤的新型药物临床研究，胸部肿瘤早诊、鉴诊标志物研发应用，新型数字技术与肺癌诊疗全流程管理。

代表作
1，Yan Wang, Bing Liu, Qingjie Min, Xin Yang, Shi Yan, Yuanyuan Ma, Shaolei li, Jiawen Fan, Yagi Wang,Bin Dong, Huajing Teng, Dongmei Lin, Qimin Zhan and Nan Wu. Spatial transcriptomics delineates molecularfeatures and cellular plasticity in lungadenocarcinoma progression. Cell Discovery 2023 Sep 19;9(1):96. doi: 10.1038/s41421-023-00591-7.

2，Liu B, Tao W, Zhou X, Xu LD, Luo Y, Yang X, Min Q, Huang M, Zhu Y, Cui X, Wang Y, Gong T, Zhang E, Huang YS, Chen W, Yan S, Wu N. Multi-omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma. Mol Cancer. 2025 May 1;24(1):129. doi: 10.1186/s12943-025-02333-7.

3，Xuantong Zhou, Furong Huang, Gang Ma, Wenqing Wei, Nan Wu and  Zhihua Liu. Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis. Signal Transduction and Targeted Therapy 2022;7:370 ; https://doi.org/10.1038/s41392-022-01199-1

4，Shenyi Yin, Ying Yu, Nan Wu, Minglei Zhuo, Yanmin Wang, Yanjie Niu, Yiqian Ni, Fang Hu, Cuiming Ding, Hongsheng Liu, Xinghua Cheng, Jin Peng, Juan Li, Yang He, Jiaxin Li, Junyi Wang, Hanshuo Zhang, Xiaoyu Zhai, Bing Liu, Yaqi Wang, Shi Yan, Mailin Chen, Wenqing Li, Jincui Peng, Fei Peng, Ruibin Xi, Buqing Ye, Liyan Jiang, Jianzhong Jeff Xi. Patient-derived tumor-like cell clusters for personalized chemo- and immunotherapies in non-small cell lung cancer. Cell Stem Cell 2024;31.

5, Zaizai Dong, Yusen Wang, Gaolian Xu, Bing Liu, Yang Wang, Julien Reboud, Pawel Jajesniak, Shi Yan, Pingchuan Ma , Feng Liu, Yuhao Zhou, Zhiyuan Jin, Kuan Yang, Zhaocun Huang, Minglei Zhuo, Bo Jia , Jian Fang, Panpan Zhang, Nan Wu, Mingzhu Yang , Jonathan M Cooper , Lingqian Chang .Genetic and phenotypic profiling of single living circulating tumour cells from patients with microfluidics. PNAS 2024 May 7;121(19):e2315168121.doi: 10.1073/pnas.2315168121

6, Xiang Li, Shanyuan Zhang, Xiang Luo, Guangming Gao, Xiangfeng Luo, Shansi Wang, Shaolei Li, Dachuan Zhao, Yaqi Wang, Xinrun Cui, Bing Liu, Ye Tao, Bufan Xiao, Lei Tang, Shi Yan, and Nan Wu. Accuracy and efficiency of an artificial intelligence-based pulmonary broncho-vascular three-dimensional reconstruction system supporting thoracic surgery: Retrospective and prospective validation study. eBioMedicine 2023;87: 104422, https://doi.org/10. 1016/j.ebiom.2022. 104422

7, Lv C, Lu F, Zhou X, Li X, Yu W, Zhang C, Chen K, Du S, Han C, Wang J, Wang Y, Li S, Wang L, Liu Y, Zhang S, Huang M, Song D, Zhao D, Liu B, Wang Y, Cui X, Zhou Z, Yan S, Wu N. Efficacy of a smartphone application assisting home-based rehabilitation and symptom management for patients with lung cancer undergoing video-assisted thoracoscopic lobectomy: a prospective, single-blinded, randomised control trial (POPPER study). Int J Surg. 2025 Jan 1;111(1):597-608. doi: 10.1097/JS9.0000000000001845.

8, Ma Y, Kang B, Li S, Xie G, Bi J, Li F, An G, Liu B, Li J, Shen Y, Xu X, Yang H, Yang Y, Gu Y, Wu N, CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma, Molecular Therapy (2022), doi: https:// doi.org/10.1016/j.ymthe.2022.06.011